Type of Credit: Elective
Credit(s)
Number of Students
介紹細胞內大分子 (醣類、脂質、氨基酸、核酸) 的結構及合成與代謝反應與其參與之酵素，除影響大分子功能，亦調控細胞生理功能。合成與代謝反應的缺失常造成許多疾病，故對疾病病理機制的基礎研究、臨床醫療發展應用有助益。
主題 ：
1. 醣類結構與代謝
2. 脂質結構與代謝
3. 氨基酸結構與代謝
4. 核酸結構與代謝
This course aims to introduce structures, function and metabolisms of macromolecules (including carbohydrates, lipid, amino acids and nucleotides). It also covers enzymes involved in the catabolism and the anabolism of macromolecules. The defects in the metabolic pathways are often associated with diseases. Therefore, understanding of the metabolic pathways for macromolecules could be useful for the study of disease pathogenesis and be beneficial for development of clinical therapeutics.
Topics:
1. Carbohydrate and Carbohydrate Metabolism
2. lipid and Lipid Metabolism
3. Metabolism of Nitrogenous compounds
4. Nucleotide Metabolism
能力項目說明
先修科目或先備能力：
普通生物學、普通化學、有機化學
| 教學週次Course Week | 彈性補充教學週次Flexible Supplemental Instruction Week | 彈性補充教學類別Flexible Supplemental Instruction Type |
|---|---|---|
|
週次 |
課程主題 |
課程內容與指定閱讀 |
教學活動與作業 |
|
1 |
Carbohydrates |
Carbohydrates: Sugars, Saccharides, Glycans |
(Chap. 9) |
|
2 |
Metabolism |
Chemical Logic of Metabolism |
(Chap. 12) |
|
3 |
Metabolism |
Carbohydrate Metabolism: Glycolysis, Gluconeogenesis, Glycogen Metabolism, and the Pentose Phosphate Pathway |
(Chap. 13) |
|
4 |
Exam 1 |
Exam 1 |
(Chapters 9, 12, 13) |
|
5 |
Citric Acid Cycle and Glyoxylate Cycle |
Citric Acid Cycle and Glyoxylate Cycle |
(Chap. 14) |
|
6 |
Electron Transport, Oxidative Phosphorylation and Oxygen Metabolism |
Electron Transport, Oxidative Phosphorylation and Oxygen Metabolism |
(Chap. 15) |
|
7 |
Lipids |
Lipids |
(Chap. 10) |
|
8 |
Exam 2 |
Exam 2 |
(Chapters 14, 15) |
|
9 |
Lipid Metabolism |
Lipid Metabolism I: Fatty Acids Triacylglycerols and Lipoproteins |
(Chap. 17) |
|
10 |
Metabolism |
Interorgan and Intracellular coordination of Energy Metabolism in Vertebrates |
(Chap. 18) |
|
11 |
Lipid Metabolism II |
Lipid Metabolism II: membrane lipids, Steroids, Isoprenoids, and Eicosanoids |
(Chap. 19) |
|
12 |
Metabolism |
Metabolism of Nitrogenous compounds I: Principles of Biosynthesis, Utilization, and Turnover |
(Chap.20) |
|
13 |
Exam 3 |
Exam 3 |
(Chapters 10, 17, 18, 19) |
|
14 |
Metabolism |
Metabolism of Nitrogenous compounds I: Principles of Biosynthesis, Utilization, and Turnover |
(Chap.20) |
|
15 |
Metabolism |
Metabolism of Nitrogenous compounds II: Amino Acids, Porphyrins, and Neurotransmitters |
(Chap.21) |
|
16 |
Metabolism |
Metabolism of Nitrogenous compounds II: Amino Acids, Porphyrins, and Neurotransmitters |
(Chap.21) |
|
17 |
Nucleotide Metabolism |
Nucleotide Metabolism |
(Chap.22) |
|
18 |
Exam 4 |
Exam 4 |
(Chapters 20, 21, 22) |
1.學期作業、考試、評量
四次筆試、作業或報告
4 written exams, homework or reports
2.教學方法及教學相關配合事項（如助教、網站或圖書及資料庫等）
教學以講授為主, 輔以互動式報告討論
Biochemistry (4th. ed.), Mathews, Van Holde, Appling, and Anthony-Cahill 2012